Flow Cytometry White Papers
Safety and Toxicity Studies Using Flow Cytometry - For GLP and non-GLP Compliant Applications
Immunomodulatory drug candidates typically undergo safety and toxicology analysis to assess suitability for human use. At present, flow cytometry-based safety and toxicology assays are used in tandem with traditional assays and can be performed under good laboratory practice (GLP) conditions or can be used for non-GLP safety and toxicology assessments.
This white paper provides an overview of how flow cytometry-based assays can be used to your safety and toxicity analysis and provide you with information critical to informing preclinical development decisions.
Functional Assays by Flow Cytometry
Immune system cells have evolved to execute numerous functions that defend the host against pathogens and other threats like tumors. Scientists have worked for decades to identify and measure cellular function and numerous experimental protocols have been developed to this end. In today’s laboratory, flow cytometry has emerged as a precise, rapid, and customizable platform for many state-of-the-art functional assays.
This white paper provides a summary of flow cytometry functional assays currently being used in basic and clinical research settings.
Flow Cytometry for Clinical Trials: Assay Development, Validation, Harmonization, and Clinical Data Acquisition
Flow cytometry can measure multiple cellular characteristics simultaneously, which makes it an “assay of choice” for profiling cell phenotypes or measuring production of immune molecules, and it can also be used to characterize signature biomarkers in a variety of situations. Unlike basic research, flow cytometry assays for clinical trials must fulfill regulatory requirements including instrument and method validation. If you are considering using a flow cytometry assay for your next pre-clinical research project or clinical trial, consider consulting with an expert in clinical flow cytometry as you plan your project.
This white paper gives an overview of points to consider when implementing a clinical trial flow cytometry assay from project inception to data collection.
Immuno-Oncology Research and Flow Cytometry - Transforming Cancer Treatment in the 21st Century
Cancer treatment is undergoing a revolution. Decades of basic and clinical research have revealed how the immune system can be harnessed to destroy tumors specifically or prevent metastasis. Along the way, flow cytometry has been a powerful tool for determining the mechanism of action of certain therapeutic treatments, monitoring responses in clinical trials, and tracking the effectiveness of treatment in patients.
To learn more about how Flow Cytometry can be used in Immuno-Oncology Research, download our white paper.
Outsourcing with CRO's - Flow Cytometry and Beyond
A CRO can carry out your experiments, to your exact specifications, and meet your needs for a single experiment or a multi-year clinical trial. CROs specializing in specific assay types or techniques may be your best option to guarantee high quality and reliable results.
In this white paper, we describe how to establish and reap the benefits of a successful Contract Research Organization (CRO) relationship.
Know Your Flow - Five Rules for Optimal Panel Design
Flow cytometry panel design has transformed biomedical research, especially in the fields of immunology, hematology, oncology, and genetics. Cells are at the heart of each flow cytometry experiment and are stained with a panel of fluorochrome-labeled antibodies to reveal characteristics about individual cells and the entire cell population.
In this white paper, we describe five basic rules that can help flow cytometry users get a better handle on panel design.
Improve Your Preclinical Prospects - Using Flow Cytometry in Preclinical Development
How do you find the next great treatment or medication? Many new pharmaceutical drugs and biologics in development or being FDA approved harness the power of the immune system. These therapies treat cancer, autoimmune diseases, and infections, but identifying high quality drug candidates and understanding their mechanism of action (MOA) requires using techniques that reveal the inner workings of the immune system. Flow cytometry is that unparalleled technique.
To learn more about how Flow Cytometry can be use throughout Preclinical development, download our white paper.