The cell cycle is a defining characteristic of living organisms. In multicellular organisms, including humans, the cell cycle governs the duplication of cells in a manner that assures accurate DNA replication and cell division. Cell cycle regulation is considered such an essential element of biology that Leland H. Hartwell, R. Timothy Hunt and Paul M. Nurse were recognized with the 2001 Nobel Prize in Physiology for their discoveries of "key regulators of the cell cycle."
Flow Cytometry Blog
When it comes to handing over your precious research samples to a contract research organization (CRO), how do you know you are outsourcing to the right company? Larger CROs seem to offer every type of analysis available, from genomics to histopathology. But specialty CROs may be a better option, especially if you need sophisticated techniques and data analysis.
Make Your Decision With These 5 Questions
You have just gotten approval to start a big phase 1 clinical trial and 172 precious blood samples are about to come through your door in about two months. What do you do? Do you clone yourself and your outstanding flow cytometry skills? Do you consider skipping sleep for a few weeks? Do you panic? Perhaps, you should consider outsourcing your flow cytometry analysis ...
Have you ever started a flow cytometry run and you cannot see any cells? This can be an alarming feeling, but some straightforward troubleshooting can usually help you find your missing cells. Check out these three questions to tackle common issues associated with disappearing cells.
Flow cytometry is becoming a standard tool in clinical and translational immuno-oncology (IO) research because it allows researchers to monitor dynamic changes in the immune system and can be customized to study different cancers. Flow cytometry-based immunophenotyping assays using whole blood are especially well suited to IO research because various cells subsets can be profiled in a single assay including naive CD4+ and CD8+ T cells, central and effector memory T cells, regulatory T cells, B cell subsets, NK cells, monocytes/macrophages, and dendritic cell subsets. These assays can be used for evaluating all types of IO therapies including checkpoint inhibitors, adoptive cell therapies, and cancer vaccines.