Tissue Dissociation Steps Video

 

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  •  Over 100 clients ranging from large pharma, biotech, to the hospital setting
  •  Ability to measure up to 16 parameters simultaneously
  •  Expertise in multiple species & sample types
  •  Multi-City site experience, domestic & international
  •  Philadelphia Business Journal award for "Best CRO" in 2012

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FlowMetric was established to deliver decision-enabling data on programs that matter the most to you. Partners choose us because of our expertize, our focus, our approach and results we have delivered.

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Using Fluorescence Activated Cell Sorting in Preclinical and Clinical Research

News from FlowMetric

  • Sorting for Rare Cell Phenotypes View Post Summary

    The immune system is comprised of a multitude of unique cell subsets. Each cell type, from B and T cells, to macrophages, monocytes and dendritic cells, have been phenotypically subdivided into unique subsets as we learn more about the phenotypic signatures that define these cells. Flow cytometry has been the central tool in evaluating and defining cell subsets, and major advances in immunophenotyping have occurred recently as more parameters can be measured during a single run on newer flow cytometers.

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  • Advancing Monoclonal Antibody Selection View Post Summary

    Monoclonal antibodies are the workhorse molecules of the immunotherapy field. These antibodies have been engineered to bind to immune system components and redirect immune responses to kill tumor cells, dial down autoimmune responses, or enhance the effects of other treatments. Much of the work behind production of monoclonal antibodies is rooted in the production of hybridomas, which involves identifying antigen-specific plasma/plasmablast cells (ASPCs) that produce antibodies specific to an antigen of interest and fusing these cells with myeloma cells. These fused hybridoma cell lines can be grown in large-scale culture and produce a single type of (monoclonal) antibody indefinitely under the correct conditions. The ASPC selection process can be time consuming and unpredictable, but recent advances in monoclonal antibody screening that use flow cytometry are making this process faster and more efficient.

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  • Using Flow Cytometry Toward Investigational New Drug (IND) Applications and First-in-Human (FIH) Clinical Trials View Post Summary

    Data is the cornerstone of the drug development and clinical trial processes and is critical to determining which candidates move forward. Currently, many drugs and biologics under development, operate by altering the immune system, and flow cytometry is a widely used technique for gathering a wide range of data about the immune response. Flow cytometry can be performed in full compliance with Good Laboratory Practice (GLP) standards, which make it an ideal tool for pre-clinical and clinical studies.

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