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Flow cytometry has been developed and used as a clinical tool since the invention of the first cytometers in the 1970s. At present, flow cytometry is considered essential for many routine clinical diagnostics, including assays for leukemia and lymphoma, stem cell enumeration, solid organ transplantation, HIV infection status, immunodeficiencies, and hematologic abnormalities. Many scientists involved in clinical trials or drug development are faced with developing clinical flow cytometry assays for multiple phases of clinical development.
If you find yourself starting to plan a clinical flow cytometry assay, here are the top 3 issues to think about as you plan your experiment.Read the full article »
Cell sorting fits into a special niche in the flow cytometry world. This technology enables users to isolate specific cell populations using cellular targets that can be stained with fluorescent antibodies. Cell sorting is a unique tool because it gives users the power to find and collect cells that are proverbial ‘needles in a haystack.’ Many flow cytometry users are reluctant to take on cell sorting because they are wary of using an instrument they view as complicated and finicky. But most cell sorters today are very user friendly and don’t invoke the use of oscilloscopes and black magic like their first generation counterparts. New alternative technologies, like magnetic bead separation, have given scientists an alternative to cell sorting for some routine cell separation protocols. Magnetic beads can’t handle every cell separation, and there will always be a place for sorting.Read the full article »
Hybridoma Development to create custom monoclonal antibodies is a multiphase process and with all the new technologies available to the scientist, the overall process might be a little overwhelming. Although hybridoma development cannot really be described as a black art, there are several important steps that can really impact the outcome of your monoclonal antibody production and even though the process of PEG fusion is fairly straight forward, imposing a common sense approach can make a difference.Read the full article »