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Flow cytometry is a powerful tool for surveying the cellular landscape during preclinical development of drugs and biologics. But flow cytometry can go beyond immunophenotyping to actual functional measurements that can contribute to understanding the true potential of a therapeutic candidate. To make the most of your flow cytometry studies, consider these other assays as you plan the next phase of preclinical development.Read the full article »
We’ve given you advice about what to consider when planning clinical flow cytometry experiments. Now check out these ‘do’s and don’ts’ to get the most out of your next clinical flow experiment.
Do - Know What Types Of Cells You Want To Identify.
Some cells are very robust and are easy to identify in peripheral blood samples. Other cells die if you shake the tube the wrong way or they behave as if they have their own agenda. Take the time to do pilot experiments with samples that are not precious so you can work out a protocol that is robust and precise enough to identify your cells of interest in your valuable clinical samples.Read the full article »
Many scientists performing preclinical and clinical research hit a point when they need to have an assay validated. You may have painstakingly developed and perfected a particular assay, but now you must put it through the rigors of validation for it to be considered a “validated assay.” The basic principles of assay validation were described in an earlier blog post, but how do you know you if you need an assay validated? Use these questions as a guide to help you figure out your validation situation and get a little less vexed about validation.Read the full article »